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In Mega Man Xtreme 2, you take control of either Mega Man or Zero through eight levels inspired by the first three Mega Man X games. Each character's mission consists of four levels, and when one mission is complete, you automatically begin the other character's quest.
At a research facility on Laguz Island, there have been reports that reploids' memory and programs are being erased in a phenomenon known as "ERASURE." Mega Man and Zero are sent to investigate and discover that many of the reploids have stopped functioning, while others have become Mavericks. It seems that a mysterious new enemy has developed DNA chips that can be used to revive previously defeated reploids, including powerful bosses of the past. Mega Man and Zero spring into action, ready to defeat whatever comes their way and restore order back to the reploids.
As in previous Mega Man titles, defeated bosses leave behind a weapon that can be used to exploit other bosses' weaknesses. In an addition new to the series, when standard enemies are killed, they often leave behind traces of "DNA Soul." These traces can be picked up and used to create items and power-ups between levels. Mega Man and Zero can also find special upgrades hidden throughout the stages. ~ Skyler Miller, All Game Guide