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Cartoon Network's boy genius makes an appearance on the Game Boy Advance in Dexter's Laboratory: Deesaster Strikes. A platform action-adventure based on the popular animated show, the title features Dexter and Dee Dee in another sibling-waged war. Dee Dee has been goofing off in Dexter's secret laboratory again, and this time she's found his latest invention — the Clone-a-matic. Now there are hundreds of Dee Dees running rampant and wreaking havoc in Dexter's lab and players must help Dexter to save his precious lab from destruction once again.
Dexter's in-game lab has eight areas and a hub to explore. He is searching for the miniature Dee Dee clones to capture them and send them packing. The number of captured Dee Dees determines each area's accessibility. In addition to snatching up the little clones, he must also disable robot miscreants and fix broken machines. The game also includes an array of puzzle-like challenges to test Dexter's brainpower.
The flood of enemies hindering Dexter's progress includes robots, aliens, and chemical mutants, yet Dexter can use punch and kick abilities or his laser Zap-a-tron to ward them off. Power-up items for replenishing health and tries lost in combat are hearts and cupcakes. Dexter will also be faced with the challenge of locating the necessary tools to fix the lab's broken machines. Dexter can navigate between available areas by using one of the teleporters located in each area. A teleporter is also located in each area that will transport Dexter directly to the hub, which is the main screen area and also where the holding tank for the Dee Dee clones is located. From the hub, players can access Dexter's main computer as well as save their game. The game ends when the machines in all eight areas are fixed. ~ Jennifer Beam, All Game Guide